| MLS 2019 | ||||
| 1ª Semana | ||||
| 2-mar-2019 | Chester | Union | 1 | Fabian de la Mora (P) |
| Toronto | 3 | Bradley (2), DeLeon | ||
| 2-mar-2019 | Orlando | Orlando City | 2 | Mueller, Akindele |
| New York City | 2 | Ofori, Ring | ||
| 2-mar-2019 | Columbus | Crew | 1 | Sauro |
| Red Bulls | 1 | Ivan | ||
| 2-mar-2019 | Frisco | Dallas | 1 | Barrios |
| Revolution | 1 | Gil | ||
| 2-mar-2019 | Houston | Dynamo | 1 | Manotas |
| Real Salt Lake | 1 | Rusnak | ||
| 2-mar-2019 | Commerce City | Rapids | 3 | Kamara, Feilhaber, Shinyashiki |
| Portland | 3 | Valeri, Blanco, Wynne (A) | ||
| 2-mar-2019 | Vancouver | Whitecaps | 2 | Godoy, Henry |
| Minnesota United | 3 | Quintero (P), Calvo, Ibarra | ||
| 2-mar-2019 | Carson | Galaxy | 2 | Steres, Ibrahimovic |
| Fire | 1 | Sapong | ||
| 3-mar-2019 | Seattle | Sounders | 4 | Leerdam, Morris (2), Ruidiaz |
| Cincinnati | 1 | Bertone | ||
| 3-mar-2019 | San Jose | Earthquakes | 1 | Eriksson |
| Impact | 2 | Piatti, Taider | ||
| 3-mar-2019 | Washington | DC United | 2 | Arriola, Acosta |
| Atlanta United | 0 | |||
| 3-mar-2019 | Los Angeles | Los Angeles FC | 2 | Rossi, Diomande |
| Sporting | 1 | Nemeth | ||
| 2ª Semana | ||||
| 9-mar-2019 | Bridgeview | Fire | 1 | Sapong |
| Orlando City | 1 | Dwyer | ||
| 9-mar-2019 | Foxborough | Revolution | 0 | |
| Crew | 2 | Zardes (2) | ||
| 9-mar-2019 | Frisco | Dallas | 2 | Ziegler (P), Acosta |
| Galaxy | 0 | |||
| 9-mar-2019 | Houston | Dynamo | 2 | Rodriguez, Manotas |
| Impact | 1 | Taider | ||
| 9-mar-2019 | Sandy | Real Salt Lake | 1 | Rusnak (P) |
| Whitecaps | 0 | |||
| 9-mar-2019 | San Jose | Earthquakes | 0 | |
| Minnesota United | 3 | Quintero (P), Ibarra, Cummings (A) | ||
| 10-mar-2019 | Seattle | Sounders | 2 | Leerdam, Ruidiaz |
| Rapids | 0 | |||
| 10-mar-2019 | Kansas City | Sporting | 2 | Ilie (P), Elliott (A) |
| Union | 0 | |||
| 10-mar-2019 | Bronx | New York City | 0 | |
| DC United | 0 | |||
| 10-mar-2019 | Atlanta | Atlanta United | 1 | Martinez |
| Cincinnati | 1 | Lamah | ||
| 10-mar-2019 | Los Angeles | Los Angeles FC | 4 | Kaye, Ramirez, Diomande, Vela |
| Timbers | 1 | Ebobisse | ||
| 3ª Semana | ||||
| 16-mar-2019 | Bridgeview | Fire | 2 | Edwards, Herbers |
| Sounders | 4 | Rodriguez, Morris, Lodeiro (P), Ruidiaz | ||
| 16-mar-2019 | Columbus | Crew | 1 | Sauro |
| Dallas | 0 | |||
| 16-mar-2019 | Houston | Dynamo | 3 | Rodriguez (2), Elis (P) |
| Whitecaps | 2 | Montero (P), Bangoura | ||
| 16-mar-2019 | Harrison | Red Bulls | 4 | Muyl (2), Wright-Phillips, Royer |
| Earthquakes | 1 | Espinoza | ||
| 16-mar-2019 | Orlando | Orlando City | 1 | Dwyer |
| Impact | 3 | Okwonkwo, Piatti (2) | ||
| 16-mar-2019 | Washington | DC United | 5 | Rooney (3, 1P), Rodriguez, Segura |
| Real Salt Lake | 0 | |||
| 16-mar-2019 | Carson | Galaxy | 3 | Dos Santos (P), Pontius, Lletget |
| Minnesota United | 2 | Gregus, Rodriguez | ||
| 17-mar-2019 | Bronx | New York City | 2 | Mitrita, Ring |
| Los Angeles FC | 2 | Vela (2, 1P) | ||
| 17-mar-2019 | Cincinnati | Cincinnati | 3 | Waston, Cruz, Deplagne |
| Timbers | 0 | |||
| 17-mar-2019 | Atlanta | Atlanta United | 1 | Barco |
| Union | 1 | Aaronson | ||
| 17-mar-2019 | Toronto | Toronto | 3 | Akinola, Hamilton, Altidore |
| Revolution | 2 | Gil (2, 1P) | ||
| 17-mar-2019 | Commerce City | Rapids | 1 | Rubio |
| Sporting | 1 | Russell | ||
| 4ª Semana | ||||
| 23-mar-2019 | Frisco | Dallas | 2 | Barrios, Hollingshead |
| Rapids | 1 | Smith | ||
| 23-mar-2019 | Harrison | Red Bulls | 0 | |
| Orlando City | 1 | Kljestan | ||
| 23-mar-2019 | Chester | Union | 3 | Accam (2), Ilsinho |
| Crew | 0 | |||
| 23-mar-2019 | Los Angeles | Los Angeles FC | 2 | Rossi, Zimmerman |
| Real Salt Lake | 1 | Kreilach (P) | ||
| 24-mar-2019 | Foxborough | Revolution | 0 | |
| Cincinnati | 2 | Manneh, Saief | ||
| 5ª Semana | ||||
| 29-mar-2019 | Toronto | Toronto | 4 | Altidore, Pozuelo (2, 1P), Chapman |
| New York City | 0 | |||
| 30-mar-2019 | Bridgeview | Fire | 1 | Parker (A) |
| Red Bulls | 0 | |||
| 30-mar-2019 | Foxborough | Revolution | 2 | Anibaba, Bye |
| Minnesota United | 1 | Quintero (P) | ||
| 30-mar-2019 | Kansas City | Sporting | 7 | Russell (2), Nemeth (3), Gutierrez, Busio |
| Impact | 1 | Taider | ||
| 30-mar-2019 | Earthquakes | San Jose | 0 | |
| Los Angeles FC | 5 | Vela (3), Beitashour, Rossi | ||
| 30-mar-2019 | Cincinnati | Cincinnati | 0 | |
| Union | 2 | Fabian de la Mora, Accam | ||
| 30-mar-2019 | Columbus | Crew | 2 | Santos, Zardes |
| Atlanta United | 0 | |||
| 30-mar-2019 | Commerce City | Rapids | 1 | Kamara (P) |
| Dynamo | 4 | Rodriguez, Sjoberg (A), Rosenberry (A), Elis | ||
| 30-mar-2019 | Sandy | Real Salt Lake | 2 | Savarino, Silva |
| Dallas | 4 | Gruezo, Pomykal (2), Ferreira | ||
| 30-mar-2019 | Vancouver | Whitecaps | 0 | |
| Sounders | 0 | |||
| 31-mar-2019 | Orlando | Orlando City | 1 | Dwyer |
| DC United | 2 | Birnbaum, Rooney | ||
| 31-mar-2019 | Carson | Galaxy | 2 | Ibrahimovic (2P) |
| Timbers | 1 | Ebobisse | ||
| 6ª Semana | ||||
| 5-abr-2019 | Vancouver | Whitecaps | 0 | |
| Galaxy | 2 | Steres, Ibrahimovic | ||
| 6-abr-2019 | Bronx | New York City | 0 | |
| Impact | 0 | |||
| 6-abr-2019 | Washington | DC United | 0 | |
| Los Angeles FC | 4 | Vela, Rossi (3) | ||
| 6-abr-2019 | Toronto | Toronto | 2 | Altidore, Osorio |
| Fire | 2 | Sapong, Nikolic | ||
| 6-abr-2019 | Harrison | Red Bulls | 1 | Casseres |
| Minnesota United | 2 | Danladi, Ibarra | ||
| 6-abr-2019 | Columbus | Crew | 1 | Williams |
| Revolution | 0 | |||
| 6-abr-2019 | Orlando | Orlando City | 4 | Nani (2, 1P), Akindele, Mueller |
| Rapids | 3 | Kamara, Mezquida, Bassett | ||
| 6-abr-2019 | Chester | Union | 2 | Burke, Bedoya |
| Dallas | 1 | Ziegler | ||
| 6-abr-2019 | San Jose | Earthquakes | 3 | Salinas, Hoesen, Espinoza |
| Timbers | 0 | |||
| 6-abr-2019 | Seattle | Sounders | 1 | Lodeiro |
| Real Salt Lake | 0 | |||
| 7-abr-2019 | Cincinnati | Cincinnati | 1 | Mattocks (P) |
| Sporting | 1 | Busio | ||
| 7ª Semana | ||||
| 9-abr-2019 | Washington | DC United | 0 | |
| Impact | 0 | |||
| 12-abr-2019 | Bridgeview | Fire | 1 | Nikolic (P) |
| Whitecaps | 1 | Reyna | ||
| 13-abr-2019 | Montreal | Impact | 1 | Novillo |
| Crew | 0 | |||
| 13-abr-2019 | Houston | Dynamo | 2 | Elis, Martinez |
| Earthquakes | 1 | Yueill | ||
| 13-abr-2019 | Seattle | Sounders | 3 | Bruin (2), Roldan |
| Toronto | 2 | Altidore (2) | ||
| 13-abr-2019 | Saint Paul | Minnesota United | 3 | Alonso, Rodriguez, Johnson (A) |
| New York City | 3 | Castellanos, Tajouri (2) | ||
| 13-abr-2019 | Foxborough | Revolution | 0 | |
| Atlanta United | 2 | Barco (2) | ||
| 13-abr-2019 | Frisco | Dallas | 2 | Ferreira, Ziegler (P) |
| Timbers | 1 | Paredes | ||
| 13-abr-2019 | Sandy | Real Salt Lake | 2 | Johnson, Kreilach |
| Orlando City | 1 | Nani | ||
| 13-abr-2019 | Commerce City | Rapids | 2 | Feilhaber, Kamara |
| DC United | 3 | Acosta, Durkin, Rodriguez | ||
| 14-abr-2019 | Carson | Galaxy | 2 | Ibrahimovic (2, 1P) |
| Union | 0 | |||
| 14-abr-2019 | Los Angeles | Los Angeles FC | 2 | Kaye, Vela |
| Cincinnati | 0 | |||
| 14-abr-2019 | Kansas City | Sporting | 2 | Russell, Busio |
| Red Bulls | 2 | Royer, White | ||
| 8ª Semana | ||||
| 17-abr-2019 | Vancouver | Whitecaps | 1 | Hwang In Beom |
| Los Angeles FC | 0 | |||
| 19-abr-2019 | Cincinnati | Cincinnati | 0 | |
| Real Salt Lake | 3 | Rusnak (2, 1P), Johnson | ||
| 19-abr-2019 | Toronto | Toronto | 4 | Pozuelo (2), Hamilton (2) |
| Minnesota United | 3 | Quintero (2, 1P), Rodriguez | ||
| 20-abr-2019 | Carson | Galaxy | 2 | Ibrahimovic (P), Polenta |
| Dynamo | 1 | Elis (P) | ||
| 20-abr-2019 | Bridgeview | Fire | 4 | Nikolic, Sapong, Mihailovic, Katai |
| Rapids | 1 | Kamara | ||
| 20-abr-2019 | Chester | Union | 3 | Burke, Jamiro (P), Bedoya |
| Impact | 0 | |||
| 20-abr-2019 | Orlando | Orlando City | 1 | Nani |
| Whitecaps | 0 | |||
| 20-abr-2019 | Atlanta | Atlanta United | 1 | Martinez (P) |
| Dallas | 2 | Ferreira, Acosta | ||
| 20-abr-2019 | Columbus | Crew | 1 | Santos |
| Timbers | 3 | Mabiala, Ebobisse, Moreira | ||
| 20-abr-2019 | Foxborough | Revolution | 1 | Penilla |
| Red Bulls | 0 | |||
| 20-abr-2019 | San Jose | Earthquakes | 4 | Hoesen (2), Salinas, Eriksson |
| Sporting | 1 | Gutierrez (P) | ||
| 21-abr-2019 | Washington | DC United | 0 | |
| New York City | 2 | Mitrita, Heber | ||
| 21-abr-2019 | Los Angeles | Los Angeles FC | 4 | Vela (2), Atuesta, Ramirez |
| Sounders | 1 | Shipp | ||
| 9ª Semana | ||||
| 24-abr-2019 | Bronx | New York City | 1 | Castellanos |
| Fire | 0 | |||
| 24-abr-2019 | Columbus | Crew | 0 | |
| DC United | 1 | Rooney | ||
| 24-abr-2019 | Foxborough | Revolution | 0 | |
| Impact | 3 | Shome, Jackson-Hamel (2) | ||
| 24-abr-2019 | Saint Paul | Minnesota United | 0 | |
| Galaxy | 0 | |||
| 24-abr-2019 | Seattle | Sounders | 2 | Leerdam, Shipp |
| Earthquakes | 2 | Salinas (2) | ||
| 27-abr-2019 | Bronx | New York City | 1 | Heber |
| Orlando City | 1 | Nani | ||
| 27-abr-2019 | Toronto | Toronto | 1 | Osorio |
| Timbers | 2 | Tuiloma, Ebobisse | ||
| 27-abr-2019 | Frisco | Dallas | 0 | |
| Earthquakes | 0 | |||
| 27-abr-2019 | Vancouver | Whitecaps | 1 | Henry |
| Union | 1 | Przybylko | ||
| 27-abr-2019 | Atlanta | Atlanta United | 1 | Gressel |
| Rapids | 0 | |||
| 27-abr-2019 | Harrison | Red Bulls | 1 | Lade |
| Cincinnati | 0 | |||
| 27-abr-2019 | Houston | Dynamo | 2 | Manotas, Martinez |
| Crew | 0 | |||
| 27-abr-2019 | Kansas City | Sporting | 4 | Nemeth (2), Gutierrez (2, 1P) |
| Revolution | 4 | Caicedo (2), Agudelo, Jones | ||
| 28-abr-2019 | Montreal | Impact | 1 | Browne |
| Fire | 0 | |||
| 28-abr-2019 | Saint Paul | Minnesota United | 1 | Rodriguez |
| DC United | 0 | |||
| 28-abr-2019 | Seattle | Sounders | 1 | Morris |
| Los Angeles FC | 1 | Vela | ||
| 28-abr-2019 | Carson | Galaxy | 2 | Antuna, Ibrahimovic |
| Real Salt Lake | 1 | Toia | ||
| 10ª Semana | ||||
| 1-may-2019 | Chester | Union | 2 | Przybylko, Picault |
| Cincinnati | 0 | |||
| 3-may-2019 | Commerce City | Rapids | 2 | Kamara (2P) |
| Whitecaps | 3 | Montero, Venuto, Rose | ||
| 4-may-2019 | Harrison | Red Bulls | 3 | Tarek, Rzatkowski, Etienne |
| Galaxy | 2 | Antuna, Ibrahimovic | ||
| 4-may-2019 | Houston | Dynamo | 2 | Manotas (2, 1P) |
| Dallas | 1 | Badji | ||
| 4-may-2019 | Orlando | Orlando City | 0 | |
| Toronto | 2 | Osorio, Chapman | ||
| 4-may-2019 | Montreal | Impact | 0 | |
| New York City | 2 | Moralez, Tajouri | ||
| 4-may-2019 | Chester | Union | 6 | Elliott, Ilsinho, Sergio Santos (2), Przybylko, Accam |
| Revolution | 1 | Caicedo | ||
| 4-may-2019 | Washington | DC United | 3 | Acosta, Rooney (P), Arriola |
| Crew | 1 | Hamid (A) | ||
| 4-may-2019 | Saint Paul | Minnesota United | 1 | Opara |
| Sounders | 1 | Roldan | ||
| 4-may-2019 | Sandy | Real Salt Lake | 1 | Johnson |
| Timbers | 2 | Blanco, Valeri | ||
| 4-may-2019 | San Jose | Earthquakes | 1 | Lima |
| Cincinnati | 0 | |||
| 4-may-2019 | Los Angeles | Los Angeles FC | 0 | |
| Fire | 0 | |||
| 5-may-2019 | Kansas City | Sporting | 0 | |
| Atlanta United | 3 | Martinez (2), Barco | ||
| 11ª Semana | ||||
| 8-may-2019 | Atlanta | Atlanta United | 2 | Villalba, Gressel |
| Toronto | 0 | |||
| 8-may-2019 | Columbus | Crew | 3 | Zardes, Higuain, Jimenez |
| Galaxy | 1 | Steres | ||
| 8-may-2019 | Bridgeview | Fire | 5 | Nikolic (2), Bronico, Gaitan, Frankowski |
| Revolution | 0 | |||
| 8-may-2019 | Harrison | Red Bulls | 1 | Long |
| Impact | 2 | Diallo, Urruti (P) | ||
| 10-may-2019 | Vancouver | Whitecaps | 1 | Montero |
| Timbers | 0 | |||
| 11-may-2019 | Cincinnati | Cincinnati | 2 | Cruz, Alashe |
| Impact | 1 | Okwonkwo | ||
| 11-may-2019 | Frisco | Dallas | 1 | Ferreira |
| Red Bulls | 3 | Casseres, Nealis, White | ||
| 11-may-2019 | Toronto | Toronto | 1 | Pozuelo |
| Union | 2 | Mavinga (A), Jamiro | ||
| 11-may-2019 | Carson | Galaxy | 0 | |
| New York City | 2 | Heber, Moralez (P) | ||
| 11-may-2019 | Columbus | Crew | 0 | |
| Los Angeles FC | 3 | Kaye, Diomande, Vela | ||
| 11-may-2019 | Foxborough | Revolution | 3 | Agudelo, Penilla (P), Gil |
| Earthquakes | 1 | Qazaishvili | ||
| 11-may-2019 | Bridgeview | Fire | 2 | Gaitan, Katai |
| Minnesota United | 0 | |||
| 11-may-2019 | Commerce City | Rapids | 2 | Acosta, Wilson |
| Real Salt Lake | 3 | Rusnak (P), Baird, Johnson | ||
| 11-may-2019 | Seattle | Sounders | 1 | Roldan |
| Dynamo | 0 | |||
| 12-may-2019 | Atlanta | Atlanta United | 1 | Martinez |
| Orlando City | 0 | |||
| 12-may-2019 | Washington | DC United | 1 | Arriola |
| Sporting | 0 | |||
| 12ª Semana | ||||
| 15-may-2019 | Toronto | Toronto | 0 | |
| DC United | 0 | |||
| 15-may-2019 | Houston | Dynamo | 1 | Manotas |
| Timbers | 1 | Fernandez | ||
| 15-may-2019 | Vancouver | Whitecaps | 0 | |
| Atlanta United | 1 | Martinez (P) | ||
| 15-may-2019 | Seattle | Sounders | 2 | Ruidiaz, Bwana |
| Orlando City | 1 | Mueller | ||
| 16-may-2019 | Los Angeles | Los Angeles FC | 2 | Vela, Rossi |
| Dallas | 0 | |||
| 18-may-2019 | Montreal | Impact | 0 | |
| Revolution | 0 | |||
| 18-may-2019 | Sandy | Real Salt Lake | 3 | Kreilach, Saucedo, Savarino |
| Toronto | 0 | |||
| 18-may-2019 | San Jose | Earthquakes | 4 | Wondolowski (4) |
| Fire | 1 | Katai | ||
| 19-may-2019 | Chester | Union | 0 | |
| Sounders | 0 | |||
| 19-may-2019 | Saint Paul | Minnesota United | 0 | |
| Crew | 0 | |||
| 19-may-2019 | Kansas City | Sporting | 1 | Nemeth |
| Whitecaps | 1 | Cornelius | ||
| 19-may-2019 | Houston | Dynamo | 2 | Rodriguez, McNamara |
| DC United | 1 | Rooney | ||
| 19-may-2019 | Orlando | Orlando City | 5 | Akindele (2), Nani (2), Dwyer |
| Cincinnati | 1 | Mattocks | ||
| 19-may-2019 | Harrison | Red Bulls | 1 | Barlow |
| Atlanta United | 0 | |||
| 20-may-2019 | Frisco | Dallas | 1 | Hollingshead |
| Los Angeles FC | 1 | Vela (P) | ||
| 20-may-2019 | Carson | Galaxy | 0 | |
| Rapids | 1 | Shinyashiki | ||
| 13ª Semana | ||||
| 23-may-2019 | Harrison | Red Bulls | 2 | White, Rose (A) |
| Whitecaps | 2 | Sutter, Montero (P) | ||
| 24-may-2019 | Orlando | Orlando City | 0 | |
| Galaxy | 1 | Dos Santos | ||
| 24-may-2019 | Sandy | Real Salt Lake | 2 | Saucedo, Savarino |
| Atlanta United | 1 | Martinez | ||
| 24-may-2019 | Los Angeles | Los Angeles FC | 4 | Ramirez, Vela, Blessing, Blackmon |
| Impact | 2 | Segura (A), Taider (P) | ||
| 25-may-2019 | Bridgeview | Fire | 1 | Sapong |
| New York City | 1 | Mitrita | ||
| 25-may-2019 | Vancouver | Whitecaps | 2 | Adnan, Venuto |
| Dallas | 1 | Badji | ||
| 25-may-2019 | Foxborough | Revolution | 1 | Agudelo |
| DC United | 1 | Rooney (P) | ||
| 25-may-2019 | Chester | Union | 1 | Przybylko |
| Timbers | 3 | Fernandez (2), Valeri | ||
| 25-may-2019 | Cincinnati | Cincinnati | 0 | |
| Red Bulls | 2 | Romero, Fernandez | ||
| 25-may-2019 | Saint Paul | Minnesota United | 1 | Metanire |
| Dynamo | 0 | |||
| 25-may-2019 | Commerce City | Rapids | 3 | Smith, Lewis, Mezquida |
| Crew | 2 | Pedro Santos, Zardes | ||
| 26-may-2019 | Kansas City | Sporting | 3 | Russell (3) |
| Sounders | 2 | Ruidiaz, Leerdam | ||
| 26-may-2019 | Toronto | Toronto | 1 | Laryea |
| Earthquakes | 2 | Wondolowski (2) | ||
| 14ª Semana | ||||
| 29-may-2019 | Atlanta | Atlanta United | 3 | Escobar, Martinez (2) |
| Minnesota United | 0 | |||
| 29-may-2019 | Montreal | Impact | 2 | Browne, Taider (P) |
| Real Salt Lake | 1 | Johnson | ||
| 29-may-2019 | Chester | Union | 1 | Sergio Santos |
| Rapids | 1 | Lewis | ||
| 29-may-2019 | Washington | DC United | 3 | Segura (2), Acosta |
| Fire | 3 | Sapong, Mihailovic, Calvo | ||
| 29-may-2019 | Kansas City | Sporting | 0 | |
| Galaxy | 2 | Alvarez, Ibrahimovic | ||
| 1-jun-2019 | Vancouver | Whitecaps | 2 | Montero (P) |
| Toronto | 1 | DeLeon | ||
| 1-jun-2019 | Montreal | Impact | 0 | |
| Orlando City | 3 | Nani (P), Akindele, Johnson | ||
| 2-jun-2019 | Atlanta | Atlanta United | 2 | Martinez (2) |
| Fire | 0 | |||
| 2-jun-2019 | Harrison | Red Bulls | 4 | Silva (A), Royer, Murillo, Fernandez |
| Real Salt Lake | 0 | |||
| 2-jun-2019 | Columbus | Crew | 2 | Zardes (P), Pedro Santos |
| New York City | 2 | Heber, Castellanos | ||
| 2-jun-2019 | Washington | DC United | 1 | Acosta |
| Earthquakes | 1 | Wondolowski | ||
| 2-jun-2019 | Frisco | Dallas | 2 | Arreaga (A), Smith (A) |
| Sounders | 1 | Ruidiaz | ||
| 2-jun-2019 | Houston | Dynamo | 1 | Elis |
| Sporting | 1 | Croizet | ||
| 2-jun-2019 | Commerce City | Rapids | 3 | Shinyashiki, Mezquida, Rubio |
| Cincinnati | 1 | Manneh | ||
| 2-jun-2019 | Portland | Timbers | 2 | Paredes, Fernandez |
| Los Angeles FC | 3 | Vela, Rossi, Blessing | ||
| 2-jun-2019 | Saint Paul | Minnesota United | 2 | Dotson, Molino |
| Union | 3 | Jamiro (P), Medunjanin, Trusty | ||
| 3-jun-2019 | Carson | Galaxy | 1 | Ibrahimovic |
| Revolution | 2 | Penilla, Bunbury | ||
| 15ª Semana | ||||
| 5-jun-2019 | Montreal | Impact | 2 | Taider (2, 1P) |
| Sounders | 1 | Rodriguez (P) | ||
| 6-jun-2019 | Bronx | New York City | 5 | Mitrita, Heber (2), Tajouri, Moralez |
| Cincinnati | 2 | Heber (A), Ibeagha (A) | ||
| 7-jun-2019 | Toronto | Toronto | 2 | DeLeon, Hamilton |
| Sporting | 2 | Gutierrez (2P) | ||
| 8-jun-2019 | San Jose | Earthquakes | 2 | Wondolowski, Eriksson |
| Dallas | 2 | Vega (A), Atuahene | ||
| 8-jun-2019 | Chester | Union | 3 | Jamiro, Ilsinho (2) |
| Red Bulls | 2 | Romero, White | ||
| 8-jun-2019 | Commerce City | Rapids | 1 | Kamara |
| Minnesota United | 0 | |||
| 16ª Semana | ||||
| 22-jun-2019 | Cincinnati | Cincinnati | 0 | |
| Galaxy | 2 | Boateng, Alvarez | ||
| 22-jun-2019 | Frisco | Dallas | 3 | Badji (2), Bressan |
| Toronto | 0 | |||
| 22-jun-2019 | Bridgeview | Fire | 1 | Katai |
| Real Salt Lake | 1 | Rusnak (P) | ||
| 22-jun-2019 | Vancouver | Whitecaps | 2 | Montero (P), Reyna |
| Rapids | 2 | Rubio, Shinyashiki | ||
| 22-jun-2019 | Portland | Timbers | 4 | Loria, Valeri (P), Fernandez, Ebobisse |
| Dynamo | 0 | |||
| 23-jun-2019 | Columbus | Crew | 0 | |
| Sporting | 1 | Gutierrez | ||
| 17ª Semana | ||||
| 26-jun-2019 | Foxborough | Revolution | 1 | Bye |
| Union | 1 | Przybylko | ||
| 26-jun-2019 | Montreal | Impact | 2 | Okwonkwo (2) |
| Timbers | 1 | Conechny | ||
| 26-jun-2019 | Toronto | Toronto | 3 | Endoh, Pozuelo (2, 1P) |
| Atlanta United | 2 | Martinez (P), Gressel | ||
| 26-jun-2019 | Washington | DC United | 1 | Rooney |
| Orlando City | 0 | |||
| 26-jun-2019 | Frisco | Dallas | 2 | Ferreira, Hollinghshead |
| Whitecaps | 2 | Reyna, Venuto | ||
| 26-jun-2019 | San Jose | Earthquakes | 2 | Qazaishvili (2) |
| Dynamo | 0 | |||
| 23-jun-2019 | Portland | Timbers | 4 | Loria, Valeri (P), Fernandez, Ebobisse |
| Dynamo | 0 | |||
| 23-jun-2019 | Columbus | Crew | 0 | |
| Sporting | 1 | Gutierrez | ||
| 28-jun-2019 | Harrison | Red Bulls | 3 | Romero, White, Royer |
| Fire | 1 | Nikolic | ||
| 28-jun-2019 | Commerce City | Rapids | 1 | Wilson |
| Los Angeles FC | 0 | |||
| 29-jun-2019 | Saint Paul | Minnesota United | 7 | Opara (2), Dotson, Finlay, Rodriguez, Toye, Molino |
| Cincinnati | 1 | Ledesma | ||
| 29-jun-2019 | Atlanta | Atlanta United | 2 | Meram (2) |
| Impact | 1 | Diallo | ||
| 29-jun-2019 | Bronx | New York City | 4 | Moralez (2P), Castellanos (2) |
| Union | 2 | Picault, Przybylko | ||
| 29-jun-2019 | Columbus | Crew | 0 | |
| Orlando City | 2 | Mueller, Akindele | ||
| 29-jun-2019 | Foxborough | Revolution | 2 | Mlinar Delamea, Bunbury |
| Dynamo | 1 | Ceren | ||
| 29-jun-2019 | Washington | DC United | 1 | Rooney (P) |
| Toronto | 1 | DeLeon | ||
| 29-jun-2019 | Sandy | Real Salt Lake | 2 | Johnson (2) |
| Sporting | 0 | |||
| 29-jun-2019 | San Jose | Earthquakes | 3 | Qazaishvili, Salinas, Thompson |
| Galaxy | 0 | |||
| 29-jun-2019 | Seattle | Sounders | 1 | Leerdam |
| Whitecaps | 0 | |||
| 30-jun-2019 | Portland | Timbers | 1 | Fernandez |
| Dallas | 0 | |||
| 18ª Semana | ||||
| 3-jul-2019 | Bronx | New York City | 3 | Moralez, Medina, Ofori |
| Sounders | 0 | |||
| 3-jul-2019 | Orlando | Orlando City | 1 | Mueller |
| Union | 3 | Przybylko (2), Picault | ||
| 3-jul-2019 | Bridgeview | Fire | 5 | Calvo, Sapong (2), Gaitan (P), Herbers |
| Atlanta United | 1 | Vazquez (P) | ||
| 3-jul-2019 | Saint Paul | Minnesota United | 3 | Quintero, Boxall, Molino |
| Earthquakes | 1 | Thompson | ||
| 3-jul-2019 | Kansas City | Sporting | 1 | Croizet |
| Los Angeles FC | 5 | Ramirez, Rossi, Vela, Zelaya, Mounir | ||
| 3-jul-2019 | Houston | Dynamo | 4 | Manotas, Martinez, Elis (2) |
| Red Bulls | 0 | |||
| 3-jul-2019 | Sandy | Real Salt Lake | 1 | Johnson |
| Crew | 0 | |||
| 4-jul-2019 | Frisco | Dallas | 2 | Mosquera, Badji |
| DC United | 0 | |||
| 4-jul-2019 | Commerce City | Rapids | 1 | Rubio |
| Revolution | 2 | Bunbury, Caicedo | ||
| 4-jul-2019 | Carson | Galaxy | 2 | Ibrahimovic (2) |
| Toronto | 0 | |||
| 6-jul-2019 | Cincinnati | Cincinnati | 3 | Manneh, Dally, Ulloa |
| Dynamo | 2 | Quioto (P), Hagglund (A) | ||
| 6-jul-2019 | Columbus | Crew | 1 | Pedro Santos (P) |
| Sounders | 2 | Lodeiro (2, 1P) | ||
| 6-jul-2019 | Montreal | Impact | 2 | Jackson-Hamel, Camacho |
| Minnesota United | 3 | Toye (2), Finlay | ||
| 6-jul-2019 | Kansas City | Sporting | 1 | Croizet |
| Fire | 0 | |||
| 6-jul-2019 | Los Angeles | Los Angeles FC | 6 | Rose (A), Diomande, Kaye, Vela (2), Rossi |
| Whitecaps | 1 | Reyna | ||
| 6-jul-2019 | San Jose | Earthquakes | 1 | Hoesen |
| Real Salt Lake | 0 | |||
| 7-jul-2019 | Atlanta | Atlanta United | 3 | Meram, Martinez (2, 1P) |
| Red Bulls | 3 | Royer, White, Wright-Phillips | ||
| 7-jul-2019 | Chester | Union | 2 | Fabian de la Mora, Przybylko |
| Orlando City | 2 | Dwyer, Patiño | ||
| 7-jul-2019 | Bronx | New York City | 0 | |
| Timbers | 1 | Blanco | ||
| 19ª Semana | ||||
| 13-jul-2019 | Washington | DC United | 2 | Jara, Amarikwa |
| Revolution | 2 | Bunbury, Gil | ||
| 13-jul-2019 | Houston | Dynamo | 1 | Quioto |
| Los Angeles FC | 3 | Diomande (2), Rossi | ||
| 13-jul-2019 | Carson | Galaxy | 1 | Feltscher |
| Earthquakes | 3 | Qazaishvili, Hoesen, Yueill | ||
| 13-jul-2019 | Montreal | Impact | 0 | |
| Toronto | 2 | Pozuelo, Altidore | ||
| 13-jul-2019 | Orlando | Orlando City | 1 | Michel |
| Crew | 0 | |||
| 13-jul-2019 | Bridgeview | Fire | 1 | Gaitan |
| Cincinnati | 2 | Cruz, Adi | ||
| 13-jul-2019 | Saint Paul | Minnesota United | 1 | Toye |
| Dallas | 0 | |||
| 13-jul-2019 | Sandy | Real Salt Lake | 4 | Savarino (2), Rusnak, Kreilach |
| Union | 0 | |||
| 13-jul-2019 | Vancouver | Whitecaps | 0 | |
| Sporting | 3 | Adnan (A), Gutierrez, Fernandes | ||
| 13-jul-2019 | Portland | Timbers | 2 | Smith (A), Valeri (P) |
| Rapids | 2 | Lewis, Nicholson | ||
| 14-jul-2019 | Seattle | Sounders | 2 | Ruidiaz, Shipp |
| Atlanta United | 1 | Martinez | ||
| 14-jul-2019 | Harrison | Red Bulls | 2 | Royer (2, 1P) |
| New York City | 1 | Heber | ||
| 17-jul-2019 | Atlanta | Atlanta United | 5 | Nagbe, Vazquez, Martinez (2), Gressel |
| Dynamo | 0 | |||
| 17-jul-2019 | Foxborough | Revolution | 4 | Bou, Fagundez, Gil, Bunbury |
| Whitecaps | 0 | |||
| 17-jul-2019 | Bridgeview | Fire | 2 | Mihailovic, Sapong |
| Crew | 2 | Zardes, Williams | ||
| 17-jul-2019 | Toronto | Toronto | 3 | Altidore, Pozuelo (P), Morgan |
| Red Bulls | 1 | Barlow | ||
| 18-jul-2019 | Cincinnati | Cincinnati | 1 | Ledesma (P) |
| DC United | 4 | Rodriguez (2), Rooney, Arriola | ||
| 18-jul-2019 | Portland | Timbers | 1 | Ebobisse |
| Orlando City | 1 | Patino | ||
| 20ª Semana | ||||
| 19-jul-2019 | Carson | Galaxy | 3 | Ibrahimovic (3) |
| Los Angeles FC | 2 | Vela (2, 1P) | ||
| 20-jul-2019 | Columbus | Crew | 2 | Williams, Accam |
| Impact | 1 | Diallo | ||
| 20-jul-2019 | Chester | Union | 2 | Fabian de la Mora, Fontana |
| Fire | 0 | |||
| 20-jul-2019 | Toronto | Toronto | 1 | Altidore |
| Dynamo | 3 | McNamara, Martinez, Manotas | ||
| 20-jul-2019 | Kansas City | Sporting | 1 | Michel |
| Dallas | 2 | Badji, Ferreira | ||
| 20-jul-2019 | Commerce City | Rapids | 1 | Anderson |
| New York City | 2 | Heber, Mitrita | ||
| 20-jul-2019 | Sandy | Real Salt Lake | 1 | Silva |
| Minnesota United | 1 | Quintero | ||
| 20-jul-2019 | Vancouver | Whitecaps | 1 | Henry |
| Earthquakes | 3 | Qazaishvili, Wondolowski, Eriksson | ||
| 21-jul-2019 | Atlanta | Atlanta United | 2 | G. Martinez, J. Martinez |
| DC United | 0 | |||
| 21-jul-2019 | Cincinnati | Cincinnati | 0 | |
| Revolution | 2 | Gil, Mlinar Delamea | ||
| 21-jul-2019 | Orlando | Orlando City | 0 | |
| Red Bulls | 1 | White | ||
| 21-jul-2019 | Seattle | Sounders | 1 | Ruidiaz |
| Timbers | 2 | Fernandez (2) | ||
| 21ª Semana | ||||
| 26-jul-2019 | Bronx | New York City | 3 | Tinnerholm, Heber, Ring |
| Sporting | 1 | Sanchez | ||
| 26-jul-2019 | Los Angeles | Los Angeles FC | 4 | Diopmande, Rossi, Vela (P), Atuesta |
| Atlanta United | 3 | Adams, Martinez, Segura (A) | ||
| 27-jul-2019 | Foxborough | Revolution | 4 | Bou, Penilla, Gil (P), Fagundez |
| Orlando City | 1 | Akindele | ||
| 27-jul-2019 | Harrison | Red Bulls | 2 | White, Royer (P) |
| Crew | 3 | Argudo, Pedro Santos (2) | ||
| 27-jul-2019 | Bridgeview | Fire | 0 | |
| DC United | 0 | |||
| 27-jul-2019 | Frisco | Dallas | 0 | |
| Real Salt Lake | 0 | |||
| 27-jul-2019 | Houston | Dynamo | 0 | |
| Sounders | 1 | Morris | ||
| 27-jul-2019 | Saint Paul | Minnesota United | 0 | |
| Whitecaps | 0 | |||
| 27-jul-2019 | Montreal | Impact | 4 | Lappalainen (2), Okwonkwo (2) |
| Union | 0 | |||
| 27-jul-2019 | Toronto | Toronto | 2 | DeLeon, Altidore |
| Cincinnati | 1 | Ledesma | ||
| 27-jul-2019 | San Jose | Earthquakes | 3 | Abubakar (A), Qazaishvili, Salinas |
| Rapids | 1 | Rubio | ||
| 27-jul-2019 | Portland | Timbers | 4 | Paredes (2), Valeri, Ebobisse |
| Galaxy | 0 | |||
| 22ª Semana | ||||
| 3-ago-2019 | Atlanta | Atlanta United | 3 | Romney (A), Gonzalez (A), Martinez |
| Galaxy | 0 | |||
| 3-ago-2019 | Harrison | Red Bulls | 2 | Mavinga (A), Lawrence |
| Toronto | 0 | |||
| 3-ago-2019 | Foxborough | Revolution | 0 | |
| Los Angeles FC | 2 | Rossi, Blessing | ||
| 3-ago-2019 | Orlando | Orlando City | 2 | Akindele, Ascues |
| Dallas | 0 | |||
| 3-ago-2019 | Cincinnati | Cincinnati | 1 | Cruz |
| Whitecaps | 2 | Hwang In Beom, Felipe Martins | ||
| 3-ago-2019 | Commerce City | Rapids | 6 | Bush (A), Kamara (3), Rubio, Shinyashiki |
| Impact | 3 | Kamara (A), Urruti, Taider (P) | ||
| 3-ago-2019 | Houston | Dynamo | 0 | |
| Fire | 1 | Nikolic | ||
| 3-ago-2019 | Sandy | Real Salt Lake | 3 | Savarino, Rusnak, Besler |
| New York City | 1 | Ring | ||
| 3-ago-2019 | San Jose | Earthquakes | 1 | Eriksson (P) |
| Crew | 1 | Zardes | ||
| 4-ago-2019 | Saint Paul | Minnesota United | 1 | Finlay (P) |
| Timbers | 0 | |||
| 4-ago-2019 | Washington | DC United | 1 | Brillant |
| Union | 5 | Bedoya, Fabian de la Mora (2), Przybylko, Picault | ||
| 4-ago-2019 | Seattle | Sounders | 2 | Morris (2) |
| Sporting | 3 | Gutierrez (2, 1P), Hurtado | ||
| 23ª Semana | ||||
| 8-ago-2019 | Bronx | New York City | 3 | Mitrita, Castellanos (2) |
| Dynamo | 2 | Cabezas, Manotas | ||
| 10-ago-2019 | Seattle | Sounders | 3 | Shipp (2), Lodeiro |
| Revolution | 3 | Mancienne, Bou, Gil (P) | ||
| 11-ago-2019 | Toronto | Toronto | 1 | Mullins |
| Orlando City | 1 | Michel | ||
| 11-ago-2019 | Columbus | Crew | 2 | Zardes (P), Pedro Santos |
| Cincinnati | 2 | Mattocks, Ledesma | ||
| 11-ago-2019 | Frisco | Dallas | 5 | Hollingshead, Mosquera, Cannon, Servania (2) |
| Minnesota United | 3 | Finlay (2), Dotson | ||
| 11-ago-2019 | Kansas City | Sporting | 1 | Russell |
| Real Salt Lake | 2 | Baird (2) | ||
| 11-ago-2019 | Commerce City | Rapids | 2 | Acosta, Rubio |
| Earthquakes | 1 | Qazaishvili | ||
| 11-ago-2019 | Bridgeview | Fire | 3 | McCarty, Nikolic, Schweinsteiger |
| Impact | 2 | Taider (P), Sagna | ||
| 11-ago-2019 | Portland | Timbers | 3 | Blanco, Loria, Ebobisse |
| Whitecaps | 1 | Bair | ||
| 11-ago-2019 | Atlanta | Atlanta United | 2 | Martinez (2, 1P) |
| New York City | 1 | Heber | ||
| 12-ago-2019 | Chester | Union | 2 | Przybylko, Elliot |
| Dynamo | 1 | Ramirez | ||
| 12-ago-2019 | Washington | DC United | 2 | Arriola, Rodriguez |
| Galaxy | 1 | Alvarez | ||
| 12-ago-2019 | Los Angeles | Los Angeles FC | 4 | Harvey, Blessing, Vela (P), Segura |
| Red Bulls | 2 | Casseres, White | ||
| 24ª Semana | ||||
| 14-ago-2019 | Orlando | Orlando City | 1 | Akindele |
| Sporting | 0 | |||
| 14-ago-2019 | Saint Paul | Minnesota United | 1 | Quintero |
| Rapids | 0 | |||
| 14-ago-2019 | Sandy | Real Salt Lake | 3 | Johnson, Rusnak, Baird |
| Sounders | 0 | |||
| 14-ago-2019 | Carson | Galaxy | 2 | Ibrahimovic (2, 1P) |
| Dallas | 0 | |||
| 15-ago-2019 | Portland | Timbers | 3 | Moreira, Fernandez (2) |
| Fire | 2 | Nikolic, Sapong | ||
| 17-ago-2019 | Harrison | Red Bulls | 1 | Rzatkowski |
| Revolution | 1 | Bou | ||
| 17-ago-2019 | Cincinnati | Cincinnati | 1 | Cruz |
| New York City | 4 | Castellanos (2), Heber (2) | ||
| 17-ago-2019 | Columbus | Crew | 2 | Pedro Santos, Accam |
| Toronto | 2 | Osorio, Altidore | ||
| 17-ago-2019 | Montreal | Impact | 3 | Lappalainen (2), Okwonkwo |
| Dallas | 3 | Ondrasek, Ziegler (P), Hollingshead | ||
| 17-ago-2019 | Bridgeview | Fire | 2 | Nikolic (2) |
| Union | 0 | |||
| 17-ago-2019 | Saint Paul | Minnesota United | 1 | Danladi |
| Orlando City | 1 | Nani (P) | ||
| 17-ago-2019 | Kansas City | Sporting | 2 | Feilhaber, Smith |
| Earthquakes | 1 | Wondolowski | ||
| 17-ago-2019 | Houston | Dynamo | 2 | Manotas (2) |
| Rapids | 2 | Rubio (2) | ||
| 17-ago-2019 | Carson | Galaxy | 2 | Ibrahimovic (2, 1P) |
| Sounders | 2 | Ruidiaz, Skjelvik (A) | ||
| 17-ago-2019 | Sandy | Real Salt Lake | 0 | |
| Los Angeles FC | 2 | Vela (P), Diomande | ||
| 17-ago-2019 | Vancouver | Whitecaps | 1 | Reyna |
| DC United | 0 | |||
| 18-ago-2019 | Portland | Timbers | 0 | |
| Atlanta United | 2 | Gonzalez Pirez, Martinez | ||
| 25ª Semana | ||||
| 21-ago-2019 | Bronx | New York City | 1 | Castellanos |
| Crew | 0 | |||
| 21-ago-2019 | Washington | DC United | 1 | Kamara |
| Red Bulls | 2 | Romero, Royer (P) | ||
| 21-ago-2019 | Los Angeles | Los Angeles FC | 4 | Rossi, Velas (2, 1P), Perez |
| Earthquakes | 0 | |||
| 22-ago-2019 | Kansas City | Sporting | 1 | Hurtado |
| Minnesota United | 0 | |||
| 23-ago-2019 | Orlando | Orlando City | 0 | |
| Atlanta United | 1 | Martinez | ||
| 23-ago-2019 | Portland | Timbers | 1 | Valeri |
| Sounders | 2 | Roldan, Ruidiaz | ||
| 24-ago-2019 | Bronx | New York City | 2 | Moralez (P), Heber |
| Red Bulls | 1 | Muyl | ||
| 24-ago-2019 | Foxborough | Revolution | 2 | Zahibo, Bou |
| Fire | 1 | Calvo | ||
| 24-ago-2019 | Chester | Union | 3 | Przybylko, Aaronson, Ilsinho |
| DC United | 1 | Acosta | ||
| 24-ago-2019 | Toronto | Toronto | 2 | Delgado, Morrow |
| Impact | 1 | Krkic | ||
| 24-ago-2019 | Sandy | Real Salt Lake | 2 | Joao Plata (P), Savarino |
| Rapids | 0 | |||
| 24-ago-2019 | San Jose | Earthquakes | 3 | Judson, Wondolowski, Rios |
| Whitecaps | 1 | Newinski | ||
| 25-ago-2019 | Cincinnati | Cincinnati | 1 | Manneh |
| Crew | 3 | Zardes (2), Diaz | ||
| 25-ago-2019 | Frisco | Dallas | 5 | Ziegler (P), Ferreira, Ondrasek (2), Barrios |
| Dynamo | 1 | Rodriguez | ||
| 25-ago-2019 | Los Angeles | Los Angeles FC | 3 | Blessing (2), Vela |
| Galaxy | 3 | Ibrahimovic (2), Pavon | ||
| 26ª Semana | ||||
| 28-ago-2019 | Montreal | Impact | 2 | Henry (A), Urruti |
| Whitecaps | 1 | Reyna | ||
| 31-ago-2019 | Harrison | Red Bulls | 0 | |
| Rapids | 2 | Lewis (2) | ||
| 31-ago-2019 | Columbus | Crew | 1 | Pedro Santos |
| Fire | 1 | Frankowski | ||
| 31-ago-2019 | Montreal | Impact | 0 | |
| DC United | 3 | Kamara (2), Arriola | ||
| 31-ago-2019 | Foxborough | Revolution | 1 | Bou |
| Toronto | 1 | Benezet | ||
| 31-ago-2019 | Chester | Union | 3 | Aaronson, Przybylko, Sergio Santos |
| Atlanta United | 1 | Martinez | ||
| 31-ago-2019 | Frisco | Dallas | 3 | Hollingshead, Barrios, Ondrasek |
| Cincinnati | 1 | Ledesma (P) | ||
| 31-ago-2019 | Kansas City | Sporting | 1 | Russell |
| Dynamo | 0 | |||
| 31-ago-2019 | Vancouver | Whitecaps | 1 | Reyna |
| New York City | 3 | Heber, Mackay-Steven, Mitrita | ||
| 31-ago-2019 | Portland | Timbers | 1 | Valeri |
| Real Salt Lake | 0 | |||
| 31-ago-2019 | San Jose | Earthquakes | 3 | Eriksson, Wondolowski (2) |
| Orlando City | 0 | |||
| 1-sep-2019 | Seattle | Sounders | 4 | Ruidiaz, Roldan (2), Morris |
| Galaxy | 3 | Ibrahimovic, Antuna, Skjelvik | ||
| 1-sep-2019 | Los Angeles | Los Angeles FC | 0 | |
| Minnesota United | 2 | Toye (2) | ||
| 27ª Semana | ||||
| 7-sep-2019 | Bronx | New York City | 2 | Medina (2, 1P) |
| Revolution | 1 | Caicedo | ||
| 7-sep-2019 | Cincinnati | Cincinnati | 1 | Ledesma (P) |
| Toronto | 5 | Mullins, DeLeon, Delgado, Bradley, Benezet | ||
| 7-sep-2019 | Orlando | Orlando City | 2 | Nani, Michel |
| Los Angeles FC | 2 | Perez, Rossi | ||
| 7-sep-2019 | Commerce City | Rapids | 2 | Shinyashiki (2) |
| Sounders | 0 | |||
| 7-sep-2019 | Portland | Timbers | 2 | Ebobisse, Fernandez |
| Sporting | 1 | Feilhaber | ||
| 28ª Semana | ||||
| 11-sep-2019 | Bronx | New York City | 1 | Mitrita |
| Toronto | 1 | Pozuelo (P) | ||
| 11-sep-2019 | Houston | Dynamo | 2 | Manotas, Ramirez |
| Minnesota United | 0 | |||
| 11-sep-2019 | Commerce City | Rapids | 2 | Bassett, Mexquida (P) |
| Galaxy | 1 | Gonzalez | ||
| 11-sep-2019 | Sandy | Real Salt Lake | 1 | Kreilach |
| Earthquakes | 0 | |||
| 14-sep-2019 | Bronx | New York City | 2 | Parks, Mitrita |
| Earthquakes | 1 | Wondolowski | ||
| 14-sep-2019 | Bridgeview | Fire | 4 | Sapong (2), Frankowski, Nikolic |
| Dallas | 0 | |||
| 14-sep-2019 | Atlanta | Atlanta United | 1 | Martinez |
| Crew | 3 | Zardez, Diaz, Robinson (A) | ||
| 14-sep-2019 | Montreal | Impact | 0 | |
| Cincinnati | 1 | Cruz | ||
| 14-sep-2019 | Orlando | Orlando City | 3 | Nani (2), Dwyer |
| Revolution | 3 | Akindele (A), Penilla, Bou | ||
| 14-sep-2019 | Chester | Union | 1 | Przybylko |
| Los Angeles FC | 1 | Vela | ||
| 14-sep-2019 | Vancouver | Whitecaps | 2 | Hwang In Beom (P), Montero |
| Dynamo | 1 | Manotas | ||
| 15-sep-2019 | Portland | Timbers | 0 | |
| DC United | 1 | Tuiloma (A) | ||
| 15-sep-2019 | Toronto | Toronto | 3 | Endoh, Pozuelo (P), Osorio |
| Rapids | 2 | Rosenberry, Nicholson | ||
| 15-sep-2019 | Saint Paul | Minnesota United | 3 | Quintero (2), Finlay |
| Real Salt Lake | 1 | Rusnak | ||
| 15-sep-2019 | Seattle | Sounders | 4 | Morris, Lodeiro (2), Davis (A) |
| Red Bulls | 2 | Long, Romero | ||
| 15-sep-2019 | Carson | Galaxy | 7 | Ibrahimovic (2), Corona, Antuna, Lletget (2) |
| Sporting | 2 | Gutierrez (2) | ||
| 29ª Semana | ||||
| 18-ago-2019 | Cincinnati | Cincinnati | 0 | |
| Atlanta United | 2 | Martinez (2) | ||
| 18-ago-2019 | Portland | Timbers | 0 | |
| Red Bulls | 2 | Duncan, Royer (P) | ||
| 18-ago-2019 | Seattle | Sounders | 0 | |
| Dallas | 0 | |||
| 21-sep-2019 | Atlanta | Atlanta United | 3 | Meram, Hyndman, Martinez |
| Earthquakes | 1 | Guzan (A) | ||
| 21-sep-2019 | Vancouver | Whitecaps | 1 | Montero |
| Crew | 1 | Zardes (P) | ||
| 21-sep-2019 | Cincinnati | Cincinnati | 0 | |
| Fire | 0 | |||
| 21-sep-2019 | Foxborough | Revolution | 0 | |
| Real Salt Lake | 0 | |||
| 21-sep-2019 | Houston | Dynamo | 2 | Elis, Ramirez |
| Orlando City | 1 | Dwyer | ||
| 21-sep-2019 | Kansas City | Sporting | 2 | Fernandes, Smith (A) |
| Rapids | 3 | Kamara, Rubio, Smith | ||
| 21-sep-2019 | Carson | Galaxy | 2 | Ibrahimovic, Antuna |
| Impact | 1 | Lappalainen | ||
| 21-sep-2019 | Los Angeles | Los Angeles FC | 1 | Vela (P) |
| Toronto | 1 | Endoh | ||
| 22-sep-2019 | Portland | Timbers | 0 | |
| Minnesota United | 0 | |||
| 22-sep-2019 | Frisco | Dallas | 1 | Ondrasek |
| New York City | 1 | Castellanos | ||
| 22-sep-2019 | Harrison | Red Bulls | 2 | Barlow, Royer |
| Union | 0 | |||
| 22-sep-2019 | Washington | DC United | 2 | Rodriguez, Brillant |
| Sounders | 0 | |||
| 30ª Semana | ||||
| 25-sep-2019 | Bronx | New York City | 4 | Mitrita (3), Heber |
| Atlanta United | 1 | Martinez (P) | ||
| 25-sep-2019 | Saint Paul | Minnesota United | 2 | Alonso, Dotson |
| Sporting | 1 | Barath | ||
| 25-sep-2019 | Sandy | Real Salt Lake | 1 | Onuoha |
| Galaxy | 2 | Pavon, Ibrahimovic | ||
| 25-sep-2019 | Los Angeles | Los Angeles FC | 3 | Vela (P), Rossi, Atuesta |
| Dynamo | 1 | Miller (A) | ||
| 25-sep-2019 | Portland | Timbers | 2 | Ebobisse (2) |
| Revolution | 2 | Bou, Gil (P) | ||
| 26-sep-2019 | San Jose | Earthquakes | 1 | Yueill |
| Union | 2 | Bedoya, Przybylko | ||
| 29-sep-2019 | Bridgeview | Fire | 2 | Katai, Herbers |
| Toronto | 2 | Altidore, Gonzalez | ||
| 29-sep-2019 | Cincinnati | Cincinnati | 1 | Cruz |
| Orlando City | 1 | Michel | ||
| 29-sep-2019 | Columbus | Crew | 2 | Mokhtar, Pedro Santos |
| Union | 0 | |||
| 29-sep-2019 | Montreal | Impact | 1 | Krkic |
| Atlanta United | 1 | Gressel | ||
| 29-sep-2019 | Foxborough | Revolution | 2 | Bunbury, Bou |
| New York City | 0 | |||
| 29-sep-2019 | Harrison | Red Bulls | 0 | |
| DC United | 0 | |||
| 29-sep-2019 | Commerce City | Colorado Rapids | 3 | Price, Rubio, Kamara |
| Dallas | 0 | |||
| 29-sep-2019 | Kansas City | Sporting | 2 | Nemeth, Salloi |
| Timbers | 2 | Blanco, Asprilla (P) | ||
| 29-sep-2019 | Carson | Galaxy | 3 | Ibrahimovic, Antuna, Pontius |
| Whitecaps | 4 | Henry, Bair, Ricketts, Chirinos | ||
| 29-sep-2019 | Saint Paul | Minnesota United | 1 | Boxall |
| Los Angeles FC | 1 | Vela | ||
| 29-sep-2019 | Sandy | Real Salt Lake | 2 | Baird, Savarino |
| Dynamo | 1 | Martinez | ||
| 29-sep-2019 | Earthquakes | San Jose | 0 | |
| Sounders | 1 | Morris | ||
| 31ª Semana | ||||
| 6-oct-2019 | Atlanta | Atlanta United | 3 | Nagbe, Martinez, Gressel |
| Revolution | 1 | Penilla | ||
| 6-oct-2019 | Frisco | Dallas | 6 | Ondrasek (2), Hedges, Mosquera, Barrios, Ferreira |
| Sporting | 0 | |||
| 6-oct-2019 | Washington | DC United | 0 | |
| Cincinnati | 0 | |||
| 6-oct-2019 | Houston | Dynamo | 4 | Ramirez (2), Elis, Rodriguez |
| Galaxy | 2 | Ibrahimovic, Pavon | ||
| 6-oct-2019 | Los Angeles | Los Angeles FC | 3 | Vela (3) |
| Rapids | 1 | Kamara | ||
| 6-oct-2019 | Montreal | Impact | 3 | Krkic, Urruti, Okwonkwo |
| Red Bulls | 0 | |||
| 6-oct-2019 | Orlando | Orlando City | 2 | Akindele, Michel |
| Fire | 5 | Smith (A), Sapong, Katai, Frankowski (2) | ||
| 6-oct-2019 | Chester | Union | 1 | Fabian de la Mora (P) |
| New York City | 2 | Matarrita, Tajouri | ||
| 6-oct-2019 | Portland | Timbers | 3 | Mabiala, Asprilla, Blanco |
| Earthquakes | 1 | Wondolowski | ||
| 6-oct-2019 | Seattle | Sounders | 1 | Torres |
| Minnesota United | 0 | |||
| 6-oct-2019 | Toronto | Toronto | 1 | Pozuelo |
| Crew | 0 | |||
| 6-oct-2019 | Vancouver | Whitecaps | 0 | |
| Real Salt Lake | 1 | Kreilach | ||
| Playoffs | ||||
| 19-oct-2019 | Atlanta | Atlanta United | 1 | Escobar |
| Revolution | 0 | |||
| 19-oct-2019 | Seattle | Sounders | 4 | Ruidiaz, Morris (3) |
| Dallas | 3 | Cannon, Hedges, Acosta | ||
| 19-oct-2019 | Toronto | Toronto | 5 | Delgado, Laryea, Osorio (2), DeLeon |
| DC United | 1 | Rodriguez | ||
| 19-oct-2019 | Sandy | Real Salt Lake | 2 | Kreilach, Savarino |
| Timbers | 1 | Asprilla | ||
| 20-oct-2019 | Chester | Union | 4 | Bedoya, Elliot, Picault, Fabian |
| Red Bulls | 3 | Sims, Parker, Barlow | ||
| 20-oct-2019 | Saint Paul | Minnesota United | 1 | Gregus |
| Galaxy | 2 | Lletget, Dos Santos | ||
| Semifinales Conferencia | ||||
| 23-oct-2019 | New York | New York City | 1 | Tajouri |
| Toronto | 2 | Pozuelo (2, 1P) | ||
| 23-oct-2019 | Seattle | Sounders | 2 | Svensson, Lodeiro |
| Real Salt Lake | 0 | |||
| 24-oct-2019 | Atlanta | Atlanta | 2 | Gressel, Martinez |
| Union | 0 | |||
| 24-oct-2019 | Los Angeles | Los Angeles FC | 5 | Vela (2), Rossi, Diomande (2) |
| Galaxy | 3 | Pavon, Ibrahimovic, Feltscher | ||
| Finales Conferencia | ||||
| 29-oct-2019 | Los Angeles | Los Angeles FC | 1 | Atuesta |
| Sounders | 3 | Ruidiaz (2), Lodeiro | ||
| 30-oct-2019 | Atlanta | Atlanta United | 1 | Gressel |
| Toronto | 2 | Benezet, DeLeon | ||
| FINAL MLS | ||||
| 10-nov-2019 | Seattle | Sounders | 3 | Leerdam, Rodriguez, Ruidiaz |
| Toronto | 1 | Altidore | ||